Zopisign 10 Mg (Zopiclone)

What is Zopisign 10 mg?

How Zopisign 10 mg Works (Mechanism of Action)

The action happens in five simple steps:

What that means for sleep:

Key pharmacology facts:

Why a higher dose is not simply better:

Dosage Guide

The table below shows licensed zopiclone dosing for insomnia.

Patient Situation	Licensed Zopiclone Dose	Timing	Maximum Duration
Adults, recommended dose	7.5 mg	Shortly before going to bed	Four weeks including tapering
Zopisign 10 mg tablet	Above the 7.5 mg recommended dose	Only on specific written medical direction	Never more than one tablet per night
Transient insomnia	7.5 mg	Shortly before going to bed	Two to five days
Short-term insomnia	7.5 mg	Shortly before going to bed	Two to three weeks
Adults aged 65 and over	Start at 3.75 mg	Shortly before going to bed	As short as possible
Liver impairment	3.75 mg nightly recommended	Shortly before going to bed	As short as possible
Severe liver impairment	Do not use zopiclone	Not applicable	Not applicable
Kidney impairment	Start at 3.75 mg	Shortly before going to bed	As short as possible
Chronic breathing problems	Start at 3.75 mg	Shortly before going to bed	As short as possible
History of drug or alcohol misuse	Hypnotics used only with clear caution	As prescribed	Shortest possible course
Anyone under 18 years	Not licensed; do not use	Not applicable	Not applicable
Pregnancy or breastfeeding	Use is not recommended	Not applicable	Not applicable

How to read this table:

Duration rules that matter most:

Missed dose and overdose rules:

How to Take Zopisign 10 mg

Practical usage tips:

Precautions

Absolute Contraindications – Do Not Use Zopisign 10 If You:

• Are allergic to zopiclone or any tablet ingredient.
• Have myasthenia gravis, a condition causing severe muscle weakness.
• Have severe impairment of respiratory function.
• Have sleep apnoea syndrome, where breathing stops during sleep.
• Have severe liver impairment.
• Have recently had an acute stroke.
• Have drunk alcohol, or plan to drink alcohol, that day.
• Have previously sleepwalked or driven while not fully awake on zopiclone.
• Have done any other complex activity while asleep on this drug.
• Are under 18 years of age.
• Are pregnant, planning pregnancy or breastfeeding.

Conditions You Must Disclose to Your Doctor

• Any liver disease, hepatitis or history of liver problems.
• Any kidney disease or reduced kidney function.
• Any lung disease, asthma, COPD or breathing difficulty.
• Any snoring or suspected sleep apnoea.
• Any history of alcohol misuse or drug dependence.
• Any history of depression, anxiety or suicidal thoughts.
• Any psychiatric illness or personality disorder.
• Any previous episode of sleepwalking or night-time confusion.
• Any memory problems or episodes of unexplained memory loss.
• Any history of falls, especially if you are over 65.
• Any lactose intolerance, since tablets may contain lactose.
• Any opioid painkiller you take, including codeine and tramadol.
• Any other sedative, sleeping tablet or muscle relaxant.
• All prescription, herbal and over-the-counter products you use.
• Any plan to drive, work shifts or operate machinery.

Food and Drink Precautions

• Do not drink alcohol on any day you take this tablet.
• Alcohol and zopiclone together deepen sedation dangerously.
• Prior or concurrent alcohol use is a contraindication, not a caution.
• Food does not meaningfully change zopiclone absorption.
• There is no need to take the tablet on an empty stomach.
• Grapefruit juice may raise zopiclone levels through CYP3A4.
• Limit caffeine in the evening, as it works against the medicine.
• Avoid herbal sedatives such as valerian without medical advice.
• Do not use cannabis or other sedating substances with this tablet.

Before-Use Safety Checklist

1. Has a doctor prescribed this exact strength for you?
2. Have you asked whether 7.5 mg would be more appropriate?
3. Do you know how many nights your course should last?
4. Have you agreed a plan for stopping the medicine?
5. Can you sleep seven to eight uninterrupted hours tonight?
6. Have you confirmed you will not drink alcohol today?
7. Have you disclosed any breathing or sleep apnoea problems?
8. Have you disclosed any liver or kidney disease?
9. Have you told your doctor about any opioid painkillers?
10. Have you disclosed any history of dependence or misuse?
11. Do you need to drive or work early tomorrow morning?
12. Do you know the emergency warning signs in Section 8?

Common and Less Common Side Effects

A bitter or metallic taste is the most characteristic effect.

Side Effect	Frequency	What It Feels Like	What to Do
Bitter or metallic taste	Common	Persistent odd taste, often on waking	Usually harmless; report if intolerable
Dry mouth	Common	Reduced saliva, thirst on waking	Sip water; maintain dental hygiene
Next-day drowsiness	Common	Sleepiness or grogginess in the morning	Do not drive; tell your doctor
Headache	Common	Dull ache on waking	Rest and drink water; report if severe
Dizziness or unsteadiness	Common	Light-headed or off-balance feeling	Move slowly; take care on stairs
Fatigue	Common	Unusual tiredness during the day	Report if it continues
Nausea or indigestion	Less common	Queasy or upset stomach	Report if severe or persistent
Memory gaps (amnesia)	Less common	No memory of events after taking the dose	Stop and contact your doctor
Confusion	Less common	Muddled thinking, especially at night	Contact your doctor promptly
Irritability or agitation	Less common	Feeling tense, restless or short-tempered	Contact your doctor
Low mood	Less common	Feeling flat, tearful or hopeless	Contact your doctor promptly
Rebound insomnia	Less common	Worse sleep after stopping the medicine	Do not restart alone; seek advice
Falls, especially in older adults	Less common	Loss of balance getting up at night	Seek medical review of the dose
Skin rash or itching	Less common	Red or itchy patches on the skin	Stop use and contact your doctor
Tolerance	With continued use	The usual dose stops working as well	Do not increase it; seek review
Dependence	With continued use	Feeling unable to sleep without it	Seek medical help to taper safely
Complex sleep behaviours	Rare	Sleepwalking, sleep-driving, eating while asleep	Stop immediately and get urgent advice
Hallucinations	Rare	Seeing or hearing things that are not there	Stop and seek urgent medical advice
Aggression or disinhibition	Rare	Out-of-character anger or behaviour	Stop and seek urgent medical advice
Respiratory depression	Rare	Slow, shallow or difficult breathing	Emergency – call for help immediately
Severe allergic reaction	Rare	Swelling of lips, face or throat; rash	Emergency – call for help immediately
Suicidal thoughts	Rare	Thoughts of self-harm or hopelessness	Seek urgent medical help the same day

• Withdrawal symptoms can follow abrupt stopping after regular use.
• These include headache, muscle pain and extreme anxiety.
• They also include tension, restlessness, confusion and irritability.
• A gradual taper reduces these effects considerably.
• This list is not complete; report any unusual symptom.
• Report suspected reactions to your national pharmacovigilance programme.

Drug Interactions – Avoid or Use With Caution

Never combine Zopisign 10 with these:

• Alcohol in any quantity, including the evening before.
• Opioid painkillers such as morphine, oxycodone, codeine and tramadol.
• Opioid substitution treatments such as methadone and buprenorphine.
• Other sleeping tablets, including zolpidem and zaleplon.
• Benzodiazepines such as diazepam, lorazepam and temazepam.
• Any other zopiclone or eszopiclone product.

Use only with medical supervision:

• Sedating antihistamines such as promethazine and chlorphenamine.
• Antipsychotic medicines, also called neuroleptics.
• Antidepressants, particularly sedating ones.
• Anti-anxiety medicines and muscle relaxants.
• Anticonvulsant medicines used for epilepsy.
• General anaesthetics before any planned procedure.
• CYP3A4 inhibitors: ketoconazole, itraconazole, clarithromycin, ritonavir.
• CYP3A4 inducers: rifampicin, carbamazepine, phenytoin, phenobarbital.
• St John’s wort, which can reduce the medicine’s effect.
• Grapefruit juice, which can raise zopiclone blood levels.

Interaction outcomes to understand:

1. Opioids plus zopiclone can cause severe respiratory depression.
2. That combination can lead to coma and death.
3. Alcohol deepens sedation and raises the risk of choking or falls.
4. Alcohol also raises the chance of complex sleep behaviours.
5. CYP3A4 inhibitors raise zopiclone levels and next-day impairment.
6. CYP3A4 inducers lower zopiclone levels and reduce its effect.
7. Stacking sedatives is a common route to accidental overdose.

Emergency Warning Signs – Seek Urgent Medical Help

Call emergency services or go to hospital immediately if you have:

• Slow, shallow or laboured breathing.
• Blue-tinged lips, face or fingertips.
• Extreme drowsiness that you cannot be roused from.
• Loss of consciousness or unresponsiveness.
• Severe confusion or disorientation.
• Swelling of the face, lips, tongue or throat.
• Widespread rash, hives or difficulty breathing or swallowing.
• A seizure or convulsion.

Stop the medicine and contact a doctor the same day if you have:

• Any episode of sleepwalking, sleep-driving or sleep-eating.
• Any activity carried out while not fully awake.
• No memory of a period after taking the tablet.
• Hallucinations or seeing things that are not there.
• Out-of-character aggression or agitation.
• New or worsening low mood or hopelessness.
• Any thoughts of harming yourself.

Critical instructions in an emergency:

1. Tell every treating doctor you have taken zopiclone.
2. State the strength, the amount and the time of the dose.
3. State whether any alcohol, opioid or sedative was also taken.
4. Bring the pack with you if that is possible.
5. Never leave someone with slowed breathing to sleep it off.

If you are struggling emotionally, please speak to someone.

• Persistent insomnia is often linked to low mood or anxiety.
• A doctor can help with both the sleep and the underlying cause.
• Local crisis helplines are available if you feel unsafe.

Why Choose This Medicine?

What zopiclone offers when it is clinically appropriate:

1. It shortens the time taken to fall asleep.
2. It reduces how often a person wakes during the night.
3. It works quickly, usually within about an hour.
4. Its half-life is shorter than many older sleeping tablets.
5. It can help break a short cycle of acute, situational insomnia.
6. It is well characterised in regulatory documents worldwide.
7. HAB Pharmaceuticals manufactures in GMP-certified Indian facilities.
8. Generic pricing keeps a short prescribed course affordable.

Honest balance for the buyer:

• The 10 mg strength is above the recommended adult dose.
• Higher doses add side effects without proven extra benefit.
• Zopiclone causes tolerance, so it works less well over time.
• It causes physical and psychological dependence.
• Stopping suddenly after regular use causes withdrawal symptoms.
• Rebound insomnia can make sleep temporarily worse on stopping.
• It is licensed for weeks of use, not months or years.
• Talking therapy for insomnia is the recommended long-term treatment.
• That approach has lasting benefit without dependence risk.
• Insomnia often signals stress, pain, depression or sleep apnoea.
• Treating the cause matters more than sedating the symptom.
• This is a controlled drug requiring a valid prescription.

Storage Instructions

• Store at room temperature in a cool, dry place.
• Keep tablets in the original blister until use.
• Protect from direct sunlight, heat and moisture.
• Do not store in the bathroom or near a sink.
• Do not refrigerate or freeze the tablets.
• Store the pack securely to prevent theft or misuse.
• A lockable cupboard is advisable for a controlled drug.
• Keep well out of sight and reach of children.
• A single tablet can seriously harm a child.
• Keep away from pets at all times.
• Never share this medicine with another person.
• Sharing a controlled drug is a criminal offence in many countries.
• Check the expiry date printed on the blister and carton.
• Do not use tablets that are chipped, discoloured or damp.
• Do not transfer tablets into unlabelled containers.
• Do not flush unused tablets down the toilet.
• Return leftover tablets to a pharmacy take-back scheme.